The best Blockchain Framework depends on the use case. Ethereum is suitable for public use cases, Hyperledger Fabric is suitable for private and permissioned use cases, Corda is suitable for enterprise use cases, and Multichain is suitable for applications that require a high degree of customization. To choose which one to use, you need to consider the type of application, the security requirements, the scalability requirements, and the cost. Ultimately, the best Blockchain Framework is the one that meets the requirements of the application while providing the best cost-benefit ratio.